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Treatment with Zoloft and any concomitant serotonergic or antidopaminergic agents, including antipsychotics, should be discontinued immediately if the above events occur and supportive symptomatic treatment should be initiated. Steady-state, therefore, should be achieved after to weeks in older patients. Often tell patients that however they feel in the first two weeks is unlikely to be how they feel in month so if they are feeling some early side effects, hold on because they will likely get better. We introduced sertraline and alcohol our coverage of SSRI Selective Serotonin Reuptake Inhibitor antidepressants with post on Prozac fluoxetine. The dosage is based on your medical condition and response to therapy. Patients not responding to an initial dose of 25 or 50 mg day may benefit from dose increases up to maximum of 200 mg day. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.